Matt Lindley

About Me Awards & Honors Publications Presentations Hobbies Contact

About Me

Person

I am a scientist working in biophotonics. My current research with Dartmouth's Georgakoudi Lab focuses on using label-free imaging to understand aging in cells and model organisms. Previously I managed the Advanced Microscopic Imaging Center at Tufts University, which was a core facility providing confocal, TPEF, FLIM, SRS, and CARS microscopy to support biomedical and industry research.

I was previously a JSPS post-doc fellow in the Nanophotonics group (Fujita Lab) at Osaka University and currently hold a post as an affiliated researcher for ongoing projects with the group. As a postdoc I studied the the impact of microplastics on host tissues using linescan Raman imaging.

I did my Ph.D. in the Structural Chemistry group (Goda Lab) at the University of Tokyo, where I combined photonics, microfluidics, and real-time signal processing to develop high-throughput coherent Raman & fluorescence flow cytometers and cell sorters.

入学前に日本で5年間働いて、もちろん日本語も話せます。よろしくお願いします。

Publications

Li M, Ueyama-Toba Y, Lindley M, Kongklad G, Nawa Y, Kumamoto Y, Ishida S, Kanda Y, Fujita S, Mizuguchi H, Fujita K. "Label-Free Evaluation of Maturation and Hepatotoxicity of Human iPSC-Derived Hepatocytes Using Hyperspectral Raman Imaging." Analytical Chemistry, 2023

Takizawa S, Hiramatsu K, Lindley M, Gala de Pablo J, Ono S, Goda K. High-speed hyperspectral imaging enabled by compressed sensing in time domain. Advanced Photonics Nexus; 2(2):026008, 2023

Gala de Pablo J, Lindley M, Hiramatsu K, Isozaki A, Goda K. Label-free live microalgal starch screening via Raman flow cytometry" Algal Research; 70:102993, 2023

Lindley M, Gala de Pablo J, Peterson W, Isozaki A, Hiramatsu K, Goda K. High-Throughput Raman-Activated Cell Sorting in the Fingerprint Region. Advanced Materials Technologies; 2101567, 2022

Peterson W, Gala de Pablo J, Lindley M, Hiramatsu K, Goda K. Ultrafast impulsive Raman spectroscopy across the terahertz–fingerprint region. Advanced Photonics; 4(1):016003, 2022

Lindley M, Gala de Pablo J, Kinegawa R, Hiramatsu K, Goda K. Highly sensitive Fourier-transform coherent anti-Stokes Raman scattering spectroscopy via genetic algorithm pulse shaping. Optics Letters; 46(17):4320-4323, 2021

Gala de Pablo J, Lindley M, Hiramatsu K, Goda K. High-Throughput Raman Flow Cytometry and Beyond. Accounts of Chemical Research; 54(9):2132–2143, 2021

Igosawa R, Hirota A, Kimura N, Kuma S, Chartkunchand KC, Mishra PM, Lindley M, Yamaguchi T, Nakano Y, Azuma T. Photodissociation spectroscopy of N2O+ in the ion storage ring RICE. Journal of Chemical Physics; 153(18):184305, 2020

Hirota A, Igosawa R, Kimura N, Kuma S, Chartkunchand KC, Mishra PM, Lindley M, Yamaguchi T, Nakano Y, Azuma T. Radiative cooling dynamics of isolated N2O+ ions in a cryogenic electrostatic ion storage ring. Physical Review A; 102(2):023119, 2020

Hiramatsu K, Yamada K, Lindley M, Suzuki K, Goda K. Large-scale label-free single-cell analysis of paramylon in Euglena gracilis by high-throughput broadband Raman flow cytometry. Biomedical Optics Express; 11(4):1752-9, 2020

Lindley M, Hiramatsu K, Nomoto H, Shibata F, Takeshita T, Kawano S, Goda K. Ultrafast Simultaneous Raman-Fluorescence Spectroscopy. Analytical Chemistry; 91(24):15563-9, 2019.

Conference Presentations

Oral

Exploring Biomarkers of senescent cells using Raman imaging Lifeomics Conference, Osaka, 2023

High-throughput Raman-activated on-chip cell sorting (2170), 32nd International Symposium on Micro-NanoMechatronics and Human Science, Nagoya, 2021

High-throughput multimodal Raman-fluorescence flow cytometry (11250-26), SPIE Photonics West BIOS, San Francisco, 2020 (Hitachi High-Tech Best Presentation Award)

Simultaneous Raman & Fluorescence Flow Cytometry (21p-E206-2), Japan Society of Applied Physics, Sapporo, 2019

High-speed simultaneous CARS and fluorescence spectroscopies (10889-33), SPIE Photonics West BIOS, San Francisco, 2019

High-speed simultaneous Raman-fluorescence spectrometer, Japan Society of Applied Physics, Nagoya, 2018

Simultaneous detection of Fourier-Transform Coherent Anti-Stokes Raman scattering and two photon fluorescence at 24,000 spectra/s, Spectroscopic Society of Japan, Tokyo, 2018

Poster

Label-free detection of microplastics in host cells and tissues, Lifeomics Conference, Osaka University, 2023

Water as a feedback medium for genetic algorithm optical pulse compression, Global Nanophotonics 2022, Osaka, 2022

Genetic algorithm pulse shaping for sensitivity enhancement in Fourier-transform coherent anti-Stokes Raman scattering spectroscopy, 46th Society of Light Microscopy Conference, Osaka, 2021

Single-laser coherent Raman-fluorescence flow cytometry, Biomedical Raman Imaging Conference, Osaka, 2019

Development of a Dual-Comb Spectrometer for Optical NMR Detection, ImPACT Retreat, 2017

Hobbies



Mostly snow, sometimes water.



Contact

Post: 200 College Ave Rm 135, Medford, MA 02155, USA

Email: matthew.lindley [(at)] tufts.edu