Matt Lindley

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About Me


I am a scientist working in biophotonics. I manage the Advanced Microscopic Imaging Center at Tufts University. We offer a wide array of optical and spectral imaging techniques (confocal, TPEF, FLIM, SRS, and CARS) to support biomedical and industry research. My current research with Tufts' ODDET group (Georgakoudi Lab) focuses on using label-free imaging to understand aging in cells and model organisms.

I was previously a JSPS post-doc fellow in the Nanophotonics group (Fujita Lab) at Osaka University and currently hold a post as an affiliated researcher for ongoing projects with the group. As a postdoc I studied the the impact of microplastics on host tissues using linescan Raman imaging.

I did my Ph.D. in the Structural Chemistry group (Goda Lab) at the University of Tokyo, where I combined photonics, microfluidics, and real-time signal processing to develop high-throughput coherent Raman & fluorescence flow cytometers and cell sorters.



Li M, Ueyama-Toba Y, Lindley M, Kongklad G, Nawa Y, Kumamoto Y, Ishida S, Kanda Y, Fujita S, Mizuguchi H, Fujita K. "Label-Free Evaluation of Maturation and Hepatotoxicity of Human iPSC-Derived Hepatocytes Using Hyperspectral Raman Imaging." Analytical Chemistry, 2023

Takizawa S, Hiramatsu K, Lindley M, Gala de Pablo J, Ono S, Goda K. High-speed hyperspectral imaging enabled by compressed sensing in time domain. Advanced Photonics Nexus; 2(2):026008, 2023

Gala de Pablo J, Lindley M, Hiramatsu K, Isozaki A, Goda K. Label-free live microalgal starch screening via Raman flow cytometry" Algal Research; 70:102993, 2023

Lindley M, Gala de Pablo J, Peterson W, Isozaki A, Hiramatsu K, Goda K. High-Throughput Raman-Activated Cell Sorting in the Fingerprint Region. Advanced Materials Technologies; 2101567, 2022

Peterson W, Gala de Pablo J, Lindley M, Hiramatsu K, Goda K. Ultrafast impulsive Raman spectroscopy across the terahertz–fingerprint region. Advanced Photonics; 4(1):016003, 2022

Lindley M, Gala de Pablo J, Kinegawa R, Hiramatsu K, Goda K. Highly sensitive Fourier-transform coherent anti-Stokes Raman scattering spectroscopy via genetic algorithm pulse shaping. Optics Letters; 46(17):4320-4323, 2021

Gala de Pablo J, Lindley M, Hiramatsu K, Goda K. High-Throughput Raman Flow Cytometry and Beyond. Accounts of Chemical Research; 54(9):2132–2143, 2021

Igosawa R, Hirota A, Kimura N, Kuma S, Chartkunchand KC, Mishra PM, Lindley M, Yamaguchi T, Nakano Y, Azuma T. Photodissociation spectroscopy of N2O+ in the ion storage ring RICE. Journal of Chemical Physics; 153(18):184305, 2020

Hirota A, Igosawa R, Kimura N, Kuma S, Chartkunchand KC, Mishra PM, Lindley M, Yamaguchi T, Nakano Y, Azuma T. Radiative cooling dynamics of isolated N2O+ ions in a cryogenic electrostatic ion storage ring. Physical Review A; 102(2):023119, 2020

Hiramatsu K, Yamada K, Lindley M, Suzuki K, Goda K. Large-scale label-free single-cell analysis of paramylon in Euglena gracilis by high-throughput broadband Raman flow cytometry. Biomedical Optics Express; 11(4):1752-9, 2020

Lindley M, Hiramatsu K, Nomoto H, Shibata F, Takeshita T, Kawano S, Goda K. Ultrafast Simultaneous Raman-Fluorescence Spectroscopy. Analytical Chemistry; 91(24):15563-9, 2019.

Conference Presentations


Exploring Biomarkers of senescent cells using Raman imaging Lifeomics Conference, Osaka, 2023

High-throughput Raman-activated on-chip cell sorting (2170), 32nd International Symposium on Micro-NanoMechatronics and Human Science, Nagoya, 2021

High-throughput multimodal Raman-fluorescence flow cytometry (11250-26), SPIE Photonics West BIOS, San Francisco, 2020 (Hitachi High-Tech Best Presentation Award)

Simultaneous Raman & Fluorescence Flow Cytometry (21p-E206-2), Japan Society of Applied Physics, Sapporo, 2019

High-speed simultaneous CARS and fluorescence spectroscopies (10889-33), SPIE Photonics West BIOS, San Francisco, 2019

High-speed simultaneous Raman-fluorescence spectrometer, Japan Society of Applied Physics, Nagoya, 2018

Simultaneous detection of Fourier-Transform Coherent Anti-Stokes Raman scattering and two photon fluorescence at 24,000 spectra/s, Spectroscopic Society of Japan, Tokyo, 2018


Label-free detection of microplastics in host cells and tissues, Lifeomics Conference, Osaka University, 2023

Water as a feedback medium for genetic algorithm optical pulse compression, Global Nanophotonics 2022, Osaka, 2022

Genetic algorithm pulse shaping for sensitivity enhancement in Fourier-transform coherent anti-Stokes Raman scattering spectroscopy, 46th Society of Light Microscopy Conference, Osaka, 2021

Single-laser coherent Raman-fluorescence flow cytometry, Biomedical Raman Imaging Conference, Osaka, 2019

Development of a Dual-Comb Spectrometer for Optical NMR Detection, ImPACT Retreat, 2017


Mostly snow, sometimes water.


Post: 200 College Ave Rm 135, Medford, MA 02155, USA

Email: matthew.lindley [(at)]